import matplotlib
matplotlib.use('TkAgg') # Или попробуй 'Qt5Agg', 'WXAgg' и т.д.
from tkinter import *
tk = Tk()
canvas = Canvas(tk, width=500, height=500, bg='white')
canvas.pack()
canvas.create_line(50, 50, 450, 450, fill='red')
tk.mainloop()