Прилагательное handsome можно употреблять только по отношению к мужчине?

не только (но в основном)
handsome adj
1 A handsome man has an attractive face with regular features.
2 A handsome woman has an attractive appearance with features that are large and regular rather than small and delicate.
3 A handsome sum of money is a large or generous amount.
4 If someone has a handsome win or a handsome victory, they get many more points or votes than their opponent.